Alert! 8 Drugs That May Increase Dementia Risk

Introduction

Certain medications, while useful for treating specific conditions, have been linked in research to cognitive decline or an increased risk of dementia—especially when used long-term or in older adults. Awareness of these drugs can help patients and caregivers make informed choices with their healthcare providers.

1. Benzodiazepines

Purpose: Used for anxiety, insomnia, or seizures.

Why Risky: Long-term use may impair memory and cognitive function.

Examples: Diazepam, Lorazepam, Alprazolam.

2. Anticholinergics

Purpose: Treat overactive bladder, allergies, depression, or Parkinson’s disease.

Why Risky: Block acetylcholine, a neurotransmitter important for memory and learning.

Examples: Diphenhydramine, Oxybutynin, Amitriptyline.

3. Proton Pump Inhibitors (PPIs)